@article {Wang201721286,
	title = {Inferring dynamic topology for decoding spatiotemporal structures in complex heterogeneous networks},
	journal = {Proceedings of the National Academy of Sciences},
	year = {2018},
	publisher = {National Academy of Sciences},
	abstract = {Inferring connections forms a critical step toward understanding large and diverse complex networks. To date, reliable and efficient methods for the reconstruction of network topology from measurement data remain a challenge due to the high complexity and nonlinearity of the system dynamics. These obstacles also form a bottleneck for analyzing and controlling the dynamic structures (e.g., synchrony) and collective behavior in such complex networks. The novel contribution of this work is to develop a unified data-driven approach to reliably and efficiently reveal the dynamic topology of complex networks in different scales{\textemdash}from cells to societies. The developed technique provides guidelines for the refinement of experimental designs toward a comprehensive understanding of complex heterogeneous networks.Extracting complex interactions (i.e., dynamic topologies) has been an essential, but difficult, step toward understanding large, complex, and diverse systems including biological, financial, and electrical networks. However, reliable and efficient methods for the recovery or estimation of network topology remain a challenge due to the tremendous scale of emerging systems (e.g., brain and social networks) and the inherent nonlinearity within and between individual units. We develop a unified, data-driven approach to efficiently infer connections of networks (ICON). We apply ICON to determine topology of networks of oscillators with different periodicities, degree nodes, coupling functions, and time scales, arising in silico, and in electrochemistry, neuronal networks, and groups of mice. This method enables the formulation of these large-scale, nonlinear estimation problems as a linear inverse problem that can be solved using parallel computing. Working with data from networks, ICON is robust and versatile enough to reliably reveal full and partial resonance among fast chemical oscillators, coherent circadian rhythms among hundreds of cells, and functional connectivity mediating social synchronization of circadian rhythmicity among mice over weeks.},
	issn = {0027-8424},
	doi = {10.1073/pnas.1721286115},
	url = {http://www.pnas.org/content/early/2018/08/23/1721286115},
	author = {Wang, Shuo and Herzog, Erik D. and Kiss, Istv{\'a}n Z. and Schwartz, William J. and Bloch, Guy and Sebek, Michael and Granados-Fuentes, Daniel and Wang, Liang and Li, Jr-Shin}
}
